Developing the compendium of
molecular transducers (the 'molecular map')
that respond to acute and chronic exercise.

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New Funding Opportunities from the NIH

PAR-20-133: Gastrointestinal (GI) and Microbiome Explorers: Development of Swallowable Smart Pills or Devices for Precision Nutrition, Microbiome and Digestive Disease Applications (R21/R33 Clinical Trial Required)

PAR-20-134: Development of Wearable Smart Devices for Continuous Monitoring of Circulating Nutrients, Metabolites and Hormones (R21/R33 Clinical Trial Required)

If you are interested in either of these opportunities, please contact Dr. Padma Maruvada at 301-594-8884 or

Animal Dataset Release 1.0

Please note the currently available animal dataset (Release 1.0) is not final. Specifically, data from more tissues will be added; and the current control dataset is limited in its coverage of fasting times and sacrifice time of day, which can confound the results when comparing to the exercised rats. Additional data will be made in future releases.

New Funding Opportunity for additional Preclinical Animal Study Sites (PASS)

There is an informational webinar available on February 13th, 2020 if you want to hear more:

New Funding Opportunity Available to Join the NIH Common Fund’s Molecular Transducers of Physical Activity Consortium

The NIH Common Fund’s Molecular Transducers of Physical Activity in Humans (MoTrPAC) program aims to uncover at the molecular level how exercise improves and preserves the health of the body’s tissues and organs. The consortium is composed of five interrelated components—Clinical Centers, Preclinical Animal Study Sites, Chemical Analysis Sites, a Bioinformatics Center, and a Consortium Coordinating Center— that together are cataloguing the biological molecules affected by exercise in people, assembling a comprehensive map of the molecular changes that occur in response to movement and, when possible, relating these changes to the benefits of physical activity. The program also aims to develop a user-friendly database that any researcher can access to develop hypotheses regarding the mechanisms whereby physical activity improves or preserves health, facilitating investigator-initiated studies and catalyzing the field of physical activity research.

MoTrPAC Phase 2 Animal Studies (U01 Clinical Trial Not Allowed) (RFA-RM-20-009)

The purpose of this FOA is to invite applications for additional Preclinical Animal Study Sites (PASS) to join the MoTrPAC program. Awards made through this FOA will support investigations into the molecular mechanisms of molecules mobilized in response to exercise identified by the existing MoTrPAC PASS and Chemical Analysis Sites ( The new PASS members will use MoTrPAC data to conduct detailed mechanistic studies to explore the functions, sources, and target tissues of molecules that transduce the beneficial effects of physical activity that have been identified in MoTrPAC.

Applications are due March 20, 2020. See the Funding Opportunity Announcement for further information.

The NIH Common Fund encourages collaboration and supports a series of exceptionally high impact, trans-NIH programs. These programs are supported by the Common Fund, and managed by the NIH Office of the Director in partnership with the various NIH Institutes, Centers, and Offices.

The National Institutes of Health (NIH) – “The Nation's Medical Research Agency” – includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about the NIH and its programs, visit the NIH website.

- Press Releases:
- Funding Opportunities:
Psychological, Behavioral, and Neurocognitive-Focused Ancillary Studies to the Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) (U01)

Mechanistic Ancillary Studies to Ongoing Interventional Clinical Trials (R01 and R21)
- Meetings:
Molecular Transducers of Physical Activity Consortium (MoTrPAC) Steering Committee Meeting
May 16-17, 2017
Dallas, TX

Molecular Transducers of Physical Activity Consortium (MoTrPAC) Steering Committee Meeting
January 9-10, 2017
Bethesda, MD